Mister Ed is an American television situation comedy.

It first aired as a syndicated program on January 5, 1961 to July 2, 1961 and then on CBS from October 1, 1961 to February 6, 1966. Mister Ed was the first series ever to debut as a midseason replacement, occurring before the premiere of Batman, five years later.

The stars of the show are Mister Ed, an intelligent talking palomino American Saddlebred ("played" by gelding Bamboo Harvester), and his owner, architect Wilbur Post (played by Alan Young). Much of the program's humor stemmed from the fact Mister Ed would speak only to Wilbur. According to the show's producer, Arthur Lubin, Young was chosen because "he seemed like a guy a horse would talk to." Lubin, a personal friend of Mae West, scored a coup and persuaded the legendary screen icon to guest star in one episode.